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The reason behind nearly two-third IVF failures is the abnormalities in the DNA of the foetus. These abnormalities prevent the successful implant and even lead to miscarriages. Though there are tests to detect genetic and chromosomal defects in the embryo prior to IVF, but they are expensive and have drawbacks. The University of Oxford researchers have successfully found out a latest detection method. This method relatively less expensive and also overcomes the drawbacks of the previous methods. This test was implemented with a couple who were trying for an IVF baby. The IVF was successful and led to the birth of their son.
This new investigation technique allows the detection of abnormal number of chromosomes, mitochondrial gene mutation and individual gene mutation of the IVF embryo only in 16 hours. This negates the need of embryo freezing, thus, lowering the cost to a great extent. According to Dagan Wells, a molecular geneticist at the NIHR Biomedical Research Centre at the University of Oxford, this procedure helps to identify the best embryos leading to viable pregnancy. According to him, this will not only increase the IVF success rate but will also bring down the risk of miscarriages.
This new sequencing technique helped the couple, struggling with infertility for four years have a healthy IVF baby. It can actually affect the pregnancy rate significantly. Michael Glassner, the fertility doctor at the Main Line Fertility Clinic where the procedure took place was sure that this technique will get standardised soon.
The research was brought under lime light at the annual meeting of the European Society of Human Reproduction and Embryology in London. However, the researchers still believe that the efficiency of this sequencing is required to be monitored before it can be standardized.
Source : TheScientist.com