Even after multiple IVF cycles, some women cannot conceive. Why do the IVF failures happen? Should we give one more try or decide to stop it? Often these questions go unanswered leaving the unfortunate couple with unending disappointment. However, the good news is the researchers of the obstetrics and gynecology department of the University Of Southampton, UK, have found an answer to these questions.

The researchers have found out an abnormal gene structure in the lining of the womb making the uterus have poor receptivity. According to Nick Macklon, the head of the obstetrics and gynaecology department of the University of Southampton, the women with this gene fingerprint are often subjected to repetitive ICSI or IVF failures, in spite of having good embryo quality.

A biopsy of the womb lining of 43 women have been done .These women have experienced recurrent implant failures even after transplanting more than three good quality embryos. Their biopsies were compared to the womb lining biopsy of 72 women who successfully delivered after IVF or ICSI. Nearly 80 percent of women who experienced ICSI or IVF failures were detected with the improper gene profile in their womb lining. On the other hand, the women who had successful IVF or ICSI were free from this disorder.

This research has confirmed that women who experience multiple implant or IVF failure may be suffering from the disorder in their uterus receptivity. Frank Holstege, head of the genomics laboratory at University Medical Centre Utrecht in Netherlands, says that, these women have a very negligible change of having a successful implant.

This research has, however, opened a new dimension in infertility treatment. It will help the clinicians and fertility experts to council patients about their chances of success through ICSI or IVF. The couples can now know their chances of success even before trying the ART procedures. This save them from spending money on a procedure that won’t be effective for them.

However, women, who don’t have this faulty gene structure, may opt for ICSI or IVF. They still retain a good chance of successful implants even after experiencing ICSI or IVF failures in the past.

Source : Times Of India